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Zhou Xiang
发布时间:2015-09-01 浏览:字体大小[ ]

 

 

 

Name: Zhou Xiang

 

 

 

 

 

 

 

 

 

Title: Professor, Ph.D.

 

Research Interests: Organic Chemistry, Chemical Biology

 

Email: xzhou@whu.edu.cn

 

Education and research experience

 

1982.9-1989.7 Bachelor, Master, Department of Chemistry, Wuhan University

1989.7-1992.12 Assistant Professor, Lecturer, Department of Chemistry, Wuhan University

1992.12-1995.5 Ph.D., Department of Chemistry, The Chinese University of Hong Kong

1996.10-1998.10 Postdoctoral, Department of Chemistry, University of Virginia, USA

Professor Dr. S. M. Hecht

1998.11-2001.5 Postdoctoral, Department of Chemistry and Biochemistry, University of

Maryland, College Park, Professor Dr. S. E. Rokita

2001.5-present Professor, Ph.D., School of Chemistry and Molecular Sciences, Wuhan University

2009-present Distinguished Professor of Education, Jiang Scholar

2011 973 Chief Scientist

 

Research areas and interests

 

Bioorganic Chemistry, Medicinal Chemistry, and Chemical Biology

 

Teaching situation

 

Leading undergraduate course: Biochemistry

Leading postgraduate course: Bioorganic Chemistry

 

Funding:

 

1. National Basic Research Program of China (973 Program): Research on New Technologies and Strategies for Serious Diseases Diagnoses Based on Nucleic Acids (2012)
2. The National Science Fund for Distinguished Young Scholars: Bioorganic Chemistry(2005)

3. The Major Project for infectious diseases of Ministry of Health of the People s Republic of China: The Major Science and Technology Projects of Prevention and Treatment of Serious Infectious Diseases AIDS and viral hepatitis (sub-project)(2012)

4. The Integration Project of the Major Research Plan of National Natural Science Foundation of China: Research on Nucleic Acid-Related Signaling Pathways Based on Ligand Regulation (2013)

5. The key program of the Major Research Plan of National Natural Science Foundation of China: The Recognition and Regulation Effects Between Small Chemical Molecules and Nucleic Acids(2015)

6. The key program of the Major Research Plan of National Natural Science Foundation of China: Research on Signal Transduction Process Based on Small Chemical Probes (2012)
7. The key program of the Major Research Plan of National Natural Science Foundation of China: Research on the Intervention and Influence of Small Chemical Probes to the Structure, Biological Activity and Related Signal Transduction of DNA Telomere (2009)

8. The General Program of National Natural Science Foundation of China: Research on the Effect of Modified Nucleic Acids on Signal Transduction Process (2015)

9. The General Program of National Natural Science Foundation of China: Design, Synthesis and Biological Activity Study of Antitumor Drugs Targeting G-quadruplex Nucleic acids (2014)
10. The General Program of National Natural Science Foundation of China: Design, Synthesis and Biological Activity Study of Inducible Nucleic Acid Crosslinkers (2011)

11. The General Program of National Natural Science Foundation of China: Design, Synthesis and Biological Activity Study of Potential Antitumor Drugs Targeting Telomerase (2010)
12. The Major Project of Scientific and Technological Innovation Program of the Higher Education Institutions: Design, Synthesis and Biological Activity Study of Antitumor Drugs Targeting Nucleic Acids (2007)
13. Trans-Century Training Programme Foundation for the Talents by the State Education Commission  

 

Affiliation

 

1. Member of the Chemistry Appraisal Group, the 6th Academic Degrees Committee of the State Council

2. Member of the Chemical Expert Panel, the 11th and 12th evaluation conference of National Natural Science Foundation of China

3. Evaluation Expert, Scientific Research Staring Foundation for the Returned Overseas Chinese Scholars of the Ministry of Education of the Peoples Republic of China

4. Member, the 3rd evaluation committee of the Science and Technology Awards of Hubei Province

5. Member, the Academic Committee of the State Key Laboratory of Natural and Biomimetic Drugs

6. Member, the Academic Committee of the Key Laboratory of Bioorganic and Molecular Engineering, the Ministry of Education of the Peoples Republic of China

7. Vice Chairman, Hubei Provincial Chemistry and Chemical Engineering Society

8. Member, the 4th Academic Committee of the Center of Chemistry Education and Research of the Higher Education Institutions

9. Member, the 2nd Academic Committee of Wuhan University

10. Director of the Chemical Biology Committee of the Chinese Chemical Society

11. Member, the 29th Council of the Chinese Chemical Society

 

Representative result

 

1. Peng, S., Bie, B. L., Sun, Y. Z., Liu, M., Cong, H. J., Zhou, W. T., Xia, Y. C., Tang, H., Deng, H. X.,* and Zhou, X.*, Metal-Organic Frameworks for Precise Inclusion of Single Stranded DNA and Transfection in Immune Cells, Nat. Commun.2018, 9:1293.

2. Liu, C. X., Zou, G. R., Peng, S., Wang, Y. F., Yang, W., Wu, F., Jiang, Z. R., Zhang, X., and Zhou, X.*, 5-Formyluracil as a Multifunctional Building Block in Biosensor Designs, Angew. Chem. Int. Ed2018, 57, 9689-9693.

3. Hong, T. T., Yuan, Y. S., Chen, Z. C., Xi, K., Wang, T. L., Xie, Y. L., He, Z. Y., Su, H. M. , Zhou, Y., Tan, Z. J., Weng, X. C.*, and Zhou, X.*, Precise antibody-independent m6A identification via 4SedTTP-involved and FTO-assisted strategy at single-nucleotide resolution, J. Am. Chem. Soc2018, 140, 5886−5889. (Cover, Spotlights on Recent JACS Publications)

4. Tian, T., Chen, Y. Q., Wang, S. R.* and Zhou, X.*, G-Quadruplex: A Regulator of Gene Expression and Its Chemical Targeting, Chem2018, 4, 1314–1344.

5. Yao, Q., Wang, Y. Q., Wang, J., Chen, S. M., Liu, H. Y., Jiang, Z. R., Zhang, X., Liu, S. M., Yuan, Q.*, and Zhou, X.*, An Ultrasensitive Diagnostic biochip based on biomimetic periodic nanostructure-assisted rolling circle amplificationACS Nano201812, 6777−6783.

6. 1. Wang, S. R.,* Wang, J. Q., Xu, G. H., Wei, L., Fu, B. S., Wu, L. Y., Song, Y. Y., Yang, X. R., Li, C. G., Liu, S. M., and Zhou, X.*, The Cucurbit [7] Uril‐Based Supramolecular Chemistry for Reversible B/Z‐DNA Transition, Adv. Sci. 20185, 1800231.  

 

7. Wang, Y. F., Liu, C. X., Zhang, X.,ang, W., Wu, F., Zou, G. R., Weng, X. C.,* and Zhou, X.*Gene specific-loci quantitative and single-base resolution analysis of 5-formylcytosine by compound-mediated polymerase chain reactionChem. Sci.2018, 9, 3723–3728.


8. Guo, S., Huang, H. Y., Deng, X. J., Chen, Y. Q., Jiang, Z. R., Xie, M., Liu, S. M., Huang, W. H.,* and Zhou, X.*, Programmable DNA-responsive microchip for the capture and release of circulating tumor cells by nucleic acid hybridizationNano Res. 2018, 11, 2592–2604.


9. Chen, Y. Q., Hong, T. T., Wang, S. R., Mo, J., Tian, T.*, Zhou, X.* Epigenetic modification of nucleic acids: from basic studies to medical applications. Chem. Soc. Rev.2017, 46, 2844-2872.


10.Liu, C. X., Wang, Y. F.,Yang, W., Wu, F., Zeng, W. W., Chen, Z. G., Huang, J. G., Zou, G. G., Zhang, X., Wang S. R., Weng X. C., Wu Z. G., Zhou, Y., Zhou, X.*, Fluorogenic labeling and single-base resolution analysis of 5-formylcytosine in DNA, Chem. Sci.2017, 8, 7443-7447.

 

Awards and honors

 

1. Chartered Chemist of the Royal Society of Chemistry (CChem), 2018

2. Fellow of the Royal Society of Chemistry (FRSC), 2018

3. Selected for the National Talent Project in 2013

4. In 2013, the first batch of high-end talents in Hubei Province led the training program.

5. Enjoy the State Council special allowance in 2012

6. First Prize of Natural Science of Hubei Province in 2010

7. Second Prize of 2010 WuXi PharmaTech Life Chemistry Research Award

8. 2009 Minister of Education, Professor Jiang Scholar

9. Received the National Outstanding Youth Fund in 2004

10. Ministry of Educations Cross-Century Excellent Talent Development Program in 2002 

11. The 10th Grand Prize for Excellent Academic Papers in Natural Science of Hubei Province in 2004