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周翔
发布时间:2015-09-01 浏览:字体大小[ ]

 

 
姓名: 周 翔
职称:教授,博导
研究方向:有机化学,化学生物学
Email:xzhou@whu.edu.cn
 
教育与研究经历
 
1982.9-1989.7   学士,硕士,武汉大学化学系
1989.7-1992.12  助教,讲师,武汉大学化学系
1993.1-1996.5 博士,香港中文大学化学系
1996.10-1998.10  博士后,美国Department of Chemistry, University of Virginia, Professor Dr. S. M. Hecht 课题组
1998.11-2001.5 博士后,美国Department of Chemistry and  Biochemistry, University of Maryland, College Park,
Professor Dr. S. E. Rokita 课题组
2001.5-至今    教授,博导, 武汉大学化学与分子科学学院
 
研究领域与兴趣
 
生物有机化学、药物化学和化学生物学
 
教学情况
 
主讲本科生课程:《化学生物学》
主讲研究生课程:《生物有机化学》
 
承担项目与课题
 
1.主持国家重点基础研究发展计划(973计划)项目:《基于核酸的重大疾病诊断新策略和新技术研究》(2012年)
2.主持国家自然科学基金杰出青年基金:《生物有机化学》(2005年)
3.主持国家卫生部传染病重大专项:《艾滋病和病毒性肝炎等重大传染病防治科技重大专项(子课题)》(2012年)
4.主持国家自然科学基金委重大研究计划集成项目:《基于配体调控的核酸相关信号通路研究》(2013年)
5.主持国家自然科学基金重大研究计划重点项目:《小分子与核酸的相互识别和调控作用》(2015年)
6.主持国家自然科学基金重大研究计划重点项目:《基于化学小分子探针的信号转导过程研究》(2012年)
7.主持国家自然科学基金重大研究计划重点项目:《化学小分子探针对染色体端粒DNA结构、生物学活性及相关信号转导的干预和影响》(2009年)
8.主持国家自然科学基金面上项目:《修饰核酸对信号转导过程的影响研究》(2015年)
9.主持国家自然科学基金面上项目:《以四链核酸为靶标的抗肿瘤药物的设计,合成及生物活性研究》(2014年)
10.主持国家自然科学基金面上项目:《可诱导核酸交联剂的设计、合成及生物活性研究》(2011年)
 
学术兼职
1.     国务院学位委员会第六、七届学科评议化学组成员
2.     第七届教育部科学技术委员会委员化学化工学部委员
3.     国家自然科学基金委第十一、十二和十五届化学科学部专家评审组成员
4.     国家自然科学基金委重大研究计划:基因信息传递过程中非编码RNA的调控作用机制专家指导组成员(2014/7-至今)
5.     中国化学会第二十八和二十九届理事会理事
6.     中国化学会化学生物学专业委员会主任(2016-2019)
7.     教育部生物有机与分子工程重点实验室学术委员会委员
8.     湖北省化学化工学会副理事长
 
 
代表性成果
 
1.       Su, H. M., Xu, J. L., Chen, Y. Q., Wang, Q., Lu, Z. A., Chen, Y. G., Chen, K., Han, S. Q., Fang, Z. T., Wang, P., Yuan, B. F., and Zhou, X.*, Photoactive GQuadruplex Ligand Identifies Multiple GQuadruplex Related Proteins with Extensive Sequence Tolerance in the Cellular Environment, J. Am. Chem. Soc.2021, 10.1021/jacs.0c10792
2.       Weng, X. C., Gong, J., Chen, Y., Wu, T., Wang, F., Yang, S. X., Yuan, Y. S., Luo, G. Z., Chen, K., Hu, L. L., Ma, H. H., Wang, P. L., Zhang, Q. F. C.*, Zhou, X.*, He, C.*, Keth-seq for transcriptome-wide RNA structure mapping. Nat. Chem Biol.2020, 16, 489-492.
3.       Peng, S., Bie, B. L., Jia, H. N., Tang, H., Zhang, X., Sun, Y. Q., Wei, Q., Wu, F., Yuan, Y. S., Deng, H. X.*, Zhou, X.*, Efficient Separation of Nucleic Acids with Different Secondary Structures by Metal–Organic Frameworks. J. Am. Chem. Soc.2020, 142, 11, 5049-5059.
4.       Wang, S. R., Wu, L. Y., Huang, H. Y., Xiong, W., Liu, J., Wei, L., Yin, P., Tian, T.*, Zhou, X.*, Conditional control of RNA-guided nucleic acid cleavage and gene editing. Nat Commun.2020, 11:91.
5.       Chen, Y. Q., Wu, F., Chen, Z. G., He, Z. Y., Wei, Q., Zeng, W. W., Chen, K., Xiao, F., Yuan, Y. S., Weng, X. C., Zhou, Y., Zhou, X.*, Acrylonitrile-Mediated Nascent RNA Sequencing for Transcriptome-Wide Profiling of Cellular RNA Dynamics. Adv. Sci.2020, 7:1900997.
6.       Su, H. M., Xu, J. L., Wang, Q., Wang, F. A., Zhou, X.*, High-efficiency and integrable DNA arithmetic and logic system based on strand displacement synthesis. Nat. Commun.2019, 10, 5390.
7.       Wang, Y. F., Zhang, X., Zou, G. R., Peng, S., Liu, C. X. and Zhou, X.*, Detection and application of 5-formylcytosine and 5-formyluracil in DNA, Acc. Chem. Res.2019, 52,1016-1024. (Supplementary Cover)
8.       Bian, W. X., Xie, Y., Wang, X. N., Xu, G. H., Fu, B. S., Li, S., Long, G., Zhou, X.* and Zhang, X. L.,* Binding of cellular nucleolin with the viral core RNA G-quadruplex structure suppresses HCV replication, Nucleic Acids Res., 2019, 4756-68.
9.       Wang, S. R., Wang, J. Q., Fu, B. S.,Chen, K., Xiong, W., Wei, L., Qing, G. Y., Tian, T.*, and Zhou, X.*, Supramolecular Coordination-Directed Reversible Regulation of Protein Activities at Epigenetic DNA Marks, J. Am. Chem. Soc2018, 140, 15842−15849.
10.    Peng, S., Bie, B. L., Sun, Y. Z., Liu, M., Cong, H. J., Zhou, W. T., Xia, Y. C., Tang, H., Deng, H. X.,* and Zhou, X.*, Metal-Organic Frameworks for Precise Inclusion of Single StrandedDNA and Transfection in Immune Cells, Nat. Commun.2018, 9:1293.
11.    Liu, C. X., Zou, G. R., Peng, S., Wang, Y. F., Yang, W., Wu, F., Jiang, Z. R., Zhang, X., and Zhou, X.*, 5-Formyluracil as a Multifunctional Building Block in Biosensor Designs, Angew. Chem. Int. Ed., 2018, 57, 9689-9693.
12.    Hong, T. T., Yuan, Y. S., Chen, Z. C., Xi, K., Wang, T. L., Xie, Y. L., He, Z. Y., Su, H. M. , Zhou, Y., Tan, Z. J., Weng, X. C.*, and Zhou, X.*, Precise antibody-independent m6A identification via 4SedTTP-involved and FTO-assisted strategy at single-nucleotide resolution, J. Am. Chem. Soc., 2018, 140, 5886−5889. (Cover, Spotlights on Recent JACS Publications)
13.    Tian, T., Chen, Y. Q., Wang, S. R.* and Zhou, X.*, G-Quadruplex: A Regulator of Gene Expression and Its Chemical Targeting, Chem2018, 4, 1314–1344.
14.    Chen, Y. Q., Hong, T. T., Wang, S. R., Mo, J., Tian, T.*, Zhou, X.* Epigenetic modification of nucleic acids: from basic studies to medical applications. Chem. Soc. Rev.2017, 46, 2844-2872.
15.    Wang, S. R., Song, Y. Y., Wei L., Liu, C. X., Fu, B. S., Wang, J. Q., Yang X. R., Liu Y. N., Liu S. M., Tian, T.*, Zhou, X.* Cucurbit[7]uril-Driven Host−Guest Chemistry for Reversible Intervention of 5-Formylcytosine-Targeted Biochemical Reactions, J. Am. Chem. Soc.,2017, 139, 16903−16912. (Spotlights on Recent JACS Publications)
16.    Tian, T., Song, Y. Y., Wei L., Wang, J. Q., Fu, B. S., He, Z. Y., Yang, X. R., Wu, F., Xu, G. H., Liu, M. S., Li, C. G., Wang, S. R.*, Zhou, X.*Reversible manipulation of the G-quadruplex structures and enzymatic reactions through supramolecular host–guest interactions, Nucleic Acids Res.2017, 45, 2283–2293.
17.    Wang, S. R., Min, Y. Q., Wang, J. Q., Liu, C. X., Fu, B. S., Wu, F., Wu, L. Y., Qiao, Z. X., Song, Y. Y., Xu, G. H., Wu, Z. G., Huang, G., Peng, N. F., Huang, R., Mao, W. X., Peng, S., Chen, Y. Q., Zhu, Y., Tian, T.*, Zhang, X. L.*, Zhou, X.*, A highly conserved G-rich consensus sequence in hepatitis C virus core gene represents a new anti–hepatitis C target, Sci. Adv., 2016, 2, e1501535.
18.    Tian, T., Song, Y. Y., Wang, J. Q., Fu, B. S., He, Z. Y., Xu, X. Q.; Li, A. L., Zhou, X., Wang, S. R.*, Zhou, X.*, Small-Molecule- Triggered and Light-Controlled Reversible Regulation of Enzymatic Activity, J. Am. Chem. Soc., 2016, 138, 955-961.
19.    Wang, T. L., Hong,T. T., Huang, Y., Su, H. M., Wu, F., Chen, Y., Wei, L., Huang, W., Hua, X. L., Xia, Y., Xu, J. L., Gan, J. H., Yuan, B. F., Feng, Y. Q., Zhang, X.L., Yang, C. G.*, Zhou, X.*, Fluorescein Derivatives as Bifunctional Molecules for the Simultaneous Inhibiting and Labeling of FTO Protein, J. Am. Chem. Soc., 2015, 137, 13736-13739.
20.    Wang, S. R., Long, Y. L., Wang, J. Q., Ge, Y. S., Guo, P., Liu, Y., Tian, T.* Zhou, X.*, Systematic investigations of different cytosine modifications on CpG dinucleotide sequences: The effects on the B-Z transition. J. Am. Chem. Soc., 2014. 136, 56-59.
21.    Wang, T. L., Hong, T. T., Tang, T., Zhai, Q. Q., Xing, X. W., Mao, W. X., Zheng, X. L., Xu, L., Wu, J. J., Weng, X. C.,Wang, S. R.,Tian, T.,Yuan,B. F., Huang, B., Zhuang, L. Zhou, X.*, Application of N-Halogeno-N- sodiobenzene sulfonamide Reagents to the Selective Detection of 5-Methylcytosine in DNA Sequences. J. Am. Chem. Soc.2013, 135, 1240-1243.
22.    Wu, Z. G., Tian, T., Yu, J. P., Weng, X. C., Liu, Y. Zhou, X.*, Formation of Sequence㊣ndependent Z〥NA Induced by a Ruthenium Complex at Low Salt Concentrations. Angew. Chem. Int. Ed., 2011, 50, 11962-11967.
23.    Wang, X. L., Huang, J., Zhou, Y. Y., Yan, S. Y., Weng, X. C., Wu, X. J., Deng, M. G., ZhouX.*, Conformational Switching of G㏎uadruplex DNA by Photoregulation. Angew. Chem. Int. Ed., 2010, 49, 5305-5309.
24.    Bai, M. H., Huang, J., Zheng, X. L., Song, Z. B., Tang, M. R., Mao, W. X., Yuan, L. B., Wu, J., Weng, X. C., Zhou, X.*, Highly selective suppression of melanoma cells by inducible DNA cross-linking agents: bis (catechol) derivatives. J. Am. Chem. Soc., 2010, 132, 15321-15327.
25.    Deng, M. G., Zhang, D., Zhou, Y. Y., Zhou, X.*, Highly effective colorimetric and visual detection of nucleic acids using an asymmetrically split peroxidase DNAzyme. J. Am. Chem. Soc., 2008, 130, 13095-13102.
26.    Weng, X. C., Ren, L. G., Weng, L. W., Huang, J., Zhu, S. G., Zhou, X.*, Weng, L. H., Synthesis and Biological Studies of Inducible DNA Cross-Linking Agents. Angew. ChemInt. Ed., 2007, 46, 8020-8023.
27.    Wang, P., Liu, R. P., Wu, X. J., Ma, H. J, Cao, X. P., Zhou, P., Zhang, J. Y., Weng, X. C., Zhang, X. L. Qi, J., Zhou, X.*, Weng, L. H., A potent, water-soluble and photoinducible DNA cross-linking agent. J. Am. Chem. Soc., 2003, 125, 1116-1117.
 
 
 
 
获奖与荣誉
 
1. 2018年英国皇家化学会特许化学家(Chartered Chemist of the Royal Society of Chemistry, CChem)
2. 2018年英国皇家化学学会会士(Fellow of the Royal Society of Chemistry, FRSC)
3. 2013年入选国家百千万人才工程
4. 2013年入选首批湖北省高端人才引领培养计划
5. 2012年享受国务院特殊津贴
6. 2010年湖北省自然科学一等奖
7. 2010年药明康德生命化学研究奖二等奖
8. 2004年获得国家杰出青年基金
9. 2002年教育部跨世纪优秀人才培养计划